Systemic medication can be utilized for the medication and cure of generalized or focal hyperhidrosis. A lot of the medicines said to be helpful in treating hyperhidrosis have not been thoroughly tested in controlled laboratory experiments. Their utilization and effectiveness are only being based on subjective proof and hearsay. Moreover, at the dosage needed to inhibit hyperhidrosis effectively, it is most likely that the side effects of such substances can be debilitating to the patient. On top of that, most of these medicines are not even accepted by the United States Food and Drug Administration (USFDA) as treatment for the cure of hyperhidrosis disorder.

The most frequently used or abused drug medication for hyperhidrosis treatment is anticholinergic drugs. This particular drug obstructs the sympathetic stimulus of the eccrine glands by restraining the activity of acetylcholine at the synapse. The applications of these particular drugs are limited and restricted. The common side effects that are generally found and associated from the anticholinergic class medication may comprise of constipation, dry mouth, urinary retention, and visual disturbances such as mydriasis and cycloplegia.

Anticholinergic drugs utilized for the treatment of hyperhidrosis include such drugs as benztropine, glycopyrronium bromide, oxybutynin and propantheline. When stressful circumstances are expected to set off hyperhidrosis, the use of anticholinergic agent or benzodiazepine before the onset will most probably be beneficial. The drug acts as a preventive measure that stops the onset of extreme perspiration brought about by anxiety or stress.

The long-term utilization and application of benzodiazepine drugs such as diazepam is restricted due to the possible drug dependence of the patient. A lot of patients have also been noted to be lacking in tolerance to the sedative effects of such medication. A number of patients take five milligrams of diazepam before sleeping at night. They do this for several weeks to get used to its sedating effect. When the need arises during stressful situations they can then take the necessary meds without fear of its effects and/or side effects.

There have been numerous unverified accounts of people with hyperhidrosis responding to varied methods of systematic medication. Most of these accounts are single cases and there are also a small number of patients with specific types of hyperhidrosis responding to a variety of systemic medication. Such medications utilized include the following:

• Benztropine for hyperhidrosis associated with venlafaxine use
• Clonidine for facial and paroxysmal localized hyperhidrosis
• Indomethacin for generalized hyperhidrosis
• Oxybutynin for episodic hyperhidrosis with hypothermia
• Propantheline for hyperhidrosis in spinal cord injury
• Fludrocortisone for orthostatic hypotension-induced hyperhidrosis
• Diltiazem in familial primary hyperhidrosis